Assay Detail
Functional
CHEMBL2434539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel 3-pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives as potent receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.86 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180602 | TAFETINIB | 1.0 | 1 | 6.28 |
| CHEMBL2430263 | — | — | 1 | 6.28 |
| CHEMBL2430264 | — | — | 1 | 5.71 |
| CHEMBL2430266 | — | — | 1 | 5.61 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180602 | TAFETINIB | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2430263 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2430264 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL2430266 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL535 | SUNITINIB | IC50 | = | 3630.0 | nM | 5.44 |