Assay Detail
Binding
CHEMBL2434577
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Binding affinity at human alpha2A AR
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.11 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276220 | — | — | 1 | 7.68 |
| CHEMBL1276218 | — | — | 1 | 7.64 |
| CHEMBL1956192 | — | — | 1 | 7.64 |
| CHEMBL1956195 | CYCLOMETHYLINE | — | 1 | 7.44 |
| CHEMBL2089156 | — | — | 1 | 7.38 |
| CHEMBL2089155 | — | — | 1 | 7.35 |
| CHEMBL1276219 | — | — | 1 | 7.35 |
| CHEMBL13917 | — | — | 1 | 7.31 |
| CHEMBL2431282 | — | — | 1 | 7.30 |
| CHEMBL1276140 | — | — | 1 | 7.28 |
| CHEMBL495095 | ALLYPHENYLINE | — | 1 | 7.24 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 7.23 |
| CHEMBL2431281 | — | — | 1 | 7.11 |
| CHEMBL1956197 | — | — | 1 | 7.08 |
| CHEMBL2431279 | — | — | 1 | 7.02 |
| CHEMBL1276139 | — | — | 1 | 7.00 |
| CHEMBL14107 | — | — | 1 | 6.90 |
| CHEMBL2431280 | — | — | 1 | 6.50 |
| CHEMBL404505 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276220 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL1276218 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL1956192 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL1956195 | CYCLOMETHYLINE | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL2089156 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL2089155 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL1276219 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL13917 | — | Ki | = | 48.98 | nM | 7.31 |
| CHEMBL2431282 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1276140 | — | Ki | = | 52.48 | nM | 7.28 |
| CHEMBL495095 | ALLYPHENYLINE | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL13852 | CIRAZOLINE | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL2431281 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL1956197 | — | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL2431279 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL1276139 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL14107 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL2431280 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL404505 | — | Ki | = | 26915.35 | nM | 4.57 |