Assay Detail
Functional
CHEMBL2434700
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Cytotoxicity against human OCI-AML2 cells assessed as cell viability after 72 hrs by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OCI-AML2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.00 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431935 | — | — | 1 | 5.72 |
| CHEMBL2431952 | — | — | 1 | 5.44 |
| CHEMBL2431955 | — | — | 1 | 5.34 |
| CHEMBL2431957 | — | — | 1 | 5.19 |
| CHEMBL2431956 | — | — | 1 | 5.02 |
| CHEMBL1829876 | — | — | 1 | 5.00 |
| CHEMBL2431993 | — | — | 1 | 4.92 |
| CHEMBL2431941 | — | — | 1 | 4.77 |
| CHEMBL2431990 | — | — | 1 | 4.75 |
| CHEMBL2431995 | — | — | 1 | 4.68 |
| CHEMBL2431994 | — | — | 1 | 4.60 |
| CHEMBL1829786 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431935 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2431952 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2431955 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2431957 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2431956 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1829876 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2431993 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2431941 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2431990 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2431995 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2431994 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1829786 | — | IC50 | = | 29000.0 | nM | 4.54 |