Assay Detail
Binding
CHEMBL2434715
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Inhibition of Pseudomonas aeruginosa TrmD using S-[methyl-3H] adenosyl-L-methionine as substrate assessed as leucine-tRNA methylation after 1 hr by scintillation proximity assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.04 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2432010 | — | — | 1 | 7.36 |
| CHEMBL2432016 | — | — | 1 | 7.20 |
| CHEMBL2432011 | — | — | 1 | 7.17 |
| CHEMBL2432000 | — | — | 1 | 7.01 |
| CHEMBL2432017 | — | — | 1 | 6.92 |
| CHEMBL2432013 | — | — | 1 | 6.60 |
| CHEMBL2431997 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2432010 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2432016 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2432011 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2432000 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL2432017 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2432013 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2431997 | — | IC50 | < | 39.0 | nM | - |