Assay Detail
Binding
CHEMBL2437893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FAM-Bid BH3 peptide from recombinant Bcl-2 (unknown origin) expressed in Escherichia coli BL21 after 10 mins by fluorescence polarization assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.84 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2436891 | — | — | 1 | 6.75 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.25 |
| CHEMBL2436890 | — | — | 1 | 6.02 |
| CHEMBL2436885 | — | — | 1 | 5.95 |
| CHEMBL2436887 | — | — | 1 | 5.88 |
| CHEMBL192032 | — | — | 1 | 5.88 |
| CHEMBL2436886 | — | — | 1 | 5.72 |
| CHEMBL2436888 | — | — | 1 | 5.09 |
| CHEMBL2436889 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2436891 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 558.0 | nM | 6.25 |
| CHEMBL2436890 | — | Ki | = | 959.0 | nM | 6.02 |
| CHEMBL2436885 | — | Ki | = | 1113.0 | nM | 5.95 |
| CHEMBL2436887 | — | Ki | = | 1323.0 | nM | 5.88 |
| CHEMBL192032 | — | Ki | = | 1325.0 | nM | 5.88 |
| CHEMBL2436886 | — | Ki | = | 1925.0 | nM | 5.72 |
| CHEMBL2436888 | — | Ki | = | 8040.0 | nM | 5.09 |
| CHEMBL2436889 | — | Ki | = | 9282.0 | nM | 5.03 |