Assay Detail
Binding
CHEMBL2437894
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FAM-Bid BH3 peptide from recombinant Mcl-1 (unknown origin) expressed in Escherichia coli BL21 after 10 mins by fluorescence polarization assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.96 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2436891 | — | — | 1 | 6.91 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.72 |
| CHEMBL2436885 | — | — | 1 | 6.21 |
| CHEMBL2436890 | — | — | 1 | 5.92 |
| CHEMBL192032 | — | — | 1 | 5.92 |
| CHEMBL2436886 | — | — | 1 | 5.70 |
| CHEMBL2436887 | — | — | 1 | 5.55 |
| CHEMBL2436888 | — | — | 1 | 5.49 |
| CHEMBL2436889 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2436891 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL2436885 | — | Ki | = | 609.0 | nM | 6.21 |
| CHEMBL2436890 | — | Ki | = | 1214.0 | nM | 5.92 |
| CHEMBL192032 | — | Ki | = | 1211.0 | nM | 5.92 |
| CHEMBL2436886 | — | Ki | = | 1981.0 | nM | 5.70 |
| CHEMBL2436887 | — | Ki | = | 2816.0 | nM | 5.55 |
| CHEMBL2436888 | — | Ki | = | 3240.0 | nM | 5.49 |
| CHEMBL2436889 | — | Ki | = | 5981.0 | nM | 5.22 |