Assay Detail
Functional
CHEMBL2438482
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Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.56 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2437042 | — | — | 1 | 8.11 |
| CHEMBL2105611 | TACALCITOL | 3.0 | 1 | 7.24 |
| CHEMBL2437049 | — | — | 1 | 6.80 |
| CHEMBL2437031 | — | — | 1 | 6.75 |
| CHEMBL2437045 | — | — | 1 | 6.52 |
| CHEMBL2434990 | — | — | 1 | 6.51 |
| CHEMBL2437043 | — | — | 1 | 5.74 |
| CHEMBL2437040 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2437042 | — | IC50 | = | 7.83 | nM | 8.11 |
| CHEMBL2105611 | TACALCITOL | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2437049 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2437031 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2437045 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2434990 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL2437043 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL2437040 | — | IC50 | = | 16350.0 | nM | 4.79 |