Assay Detail
Binding
CHEMBL2438909
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Inhibition of SARS coronavirus 3CL-protease R188I mutant using H-TSAVLQSGFRK-NH2 as substrate after 60 mins by HPLC analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.67 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2435614 | — | — | 1 | 6.13 |
| CHEMBL2435605 | — | — | 1 | 5.89 |
| CHEMBL2435617 | — | — | 1 | 5.89 |
| CHEMBL2435622 | — | — | 1 | 5.82 |
| CHEMBL2435610 | — | — | 1 | 5.34 |
| CHEMBL2435612 | — | — | 1 | 5.32 |
| CHEMBL2435616 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2435614 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL2435605 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2435617 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2435622 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2435610 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2435612 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2435616 | — | IC50 | = | 5200.0 | nM | 5.28 |