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Assay Detail

CHEMBL2439229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against HEK293T cells assessed as cell viability after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HEK-293T
Confidence 1 — Organism
Curated By Autocuration

Target

HEK-293T (CHEMBL3706568)
Type CELL-LINE
Organism Homo sapiens

Publication

Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents.
Ribeiro CJ, Kumar SP, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM.
Eur J Med Chem (2013) 69 : 365 -372
PubMed 24077527 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.86 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2435700 1 5.30
CHEMBL2435699 1 4.42
CHEMBL2435707 SQUARIC ACID DIBUTYL ESTER 2.0 1 -
CHEMBL76 CHLOROQUINE 4.0 1 -
CHEMBL374508 E-64 1 -
CHEMBL2435706 1 -
CHEMBL2435705 1 -
CHEMBL2435704 1 -
CHEMBL2435703 1 -
CHEMBL2435702 1 -
CHEMBL2435701 1 -
CHEMBL2435698 1 -
CHEMBL2435697 1 -
CHEMBL2435696 1 -
CHEMBL2435695 1 -
CHEMBL2435694 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2435700 IC50 = 5000.0 nM 5.30
CHEMBL2435699 IC50 = 37900.0 nM 4.42
CHEMBL2435707 SQUARIC ACID DIBUTYL ESTER IC50 - -
CHEMBL76 CHLOROQUINE IC50 > 50000.0 nM -
CHEMBL374508 E-64 IC50 - -
CHEMBL2435706 IC50 > 50000.0 nM -
CHEMBL2435705 IC50 > 50000.0 nM -
CHEMBL2435704 IC50 > 50000.0 nM -
CHEMBL2435703 IC50 > 50000.0 nM -
CHEMBL2435702 IC50 > 50000.0 nM -
CHEMBL2435701 IC50 > 50000.0 nM -
CHEMBL2435698 IC50 > 50000.0 nM -
CHEMBL2435697 IC50 - -
CHEMBL2435696 IC50 > 50000.0 nM -
CHEMBL2435695 IC50 > 50000.0 nM -
CHEMBL2435694 IC50 > 50000.0 nM -