Assay Detail
Functional
CHEMBL2439232
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Antiplasmodial activity against ring stage of chloroquine-resistant Plasmodium falciparum W2 infected in human RBC after 48 hrs by flow cytometric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.97 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2435702 | — | — | 1 | 7.02 |
| CHEMBL2435701 | — | — | 1 | 7.00 |
| CHEMBL2435703 | — | — | 1 | 6.98 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.85 |
| CHEMBL2435700 | — | — | 1 | 6.70 |
| CHEMBL2435704 | — | — | 1 | 6.15 |
| CHEMBL2435694 | — | — | 1 | 5.81 |
| CHEMBL2435695 | — | — | 1 | 5.74 |
| CHEMBL374508 | E-64 | — | 1 | 5.71 |
| CHEMBL2435696 | — | — | 1 | 5.69 |
| CHEMBL2435706 | — | — | 1 | 5.66 |
| CHEMBL2435699 | — | — | 1 | 5.33 |
| CHEMBL2435698 | — | — | 1 | 5.11 |
| CHEMBL2435707 | SQUARIC ACID DIBUTYL ESTER | 2.0 | 1 | 5.05 |
| CHEMBL2435705 | — | — | 1 | 4.73 |
| CHEMBL2435697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2435702 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2435701 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2435703 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2435700 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2435704 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2435694 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL2435695 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL374508 | E-64 | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL2435696 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL2435706 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL2435699 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL2435698 | — | IC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL2435707 | SQUARIC ACID DIBUTYL ESTER | IC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL2435705 | — | IC50 | = | 18590.0 | nM | 4.73 |
| CHEMBL2435697 | — | IC50 | > | 10000.0 | nM | - |