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Assay Detail

CHEMBL2439234

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Carica papaya
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Papain (CHEMBL4779)
Type SINGLE PROTEIN
Organism Carica papaya

Publication

Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents.
Ribeiro CJ, Kumar SP, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM.
Eur J Med Chem (2013) 69 : 365 -372
PubMed 24077527 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 8.15 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL374508 E-64 1 8.15
CHEMBL2435707 SQUARIC ACID DIBUTYL ESTER 2.0 1 -
CHEMBL76 CHLOROQUINE 4.0 1 -
CHEMBL2435706 1 -
CHEMBL2435705 1 -
CHEMBL2435704 1 -
CHEMBL2435703 1 -
CHEMBL2435702 1 -
CHEMBL2435701 1 -
CHEMBL2435700 1 -
CHEMBL2435699 1 -
CHEMBL2435698 1 -
CHEMBL2435697 1 -
CHEMBL2435696 1 -
CHEMBL2435695 1 -
CHEMBL2435694 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL374508 E-64 IC50 = 7.0 nM 8.15
CHEMBL2435707 SQUARIC ACID DIBUTYL ESTER IC50 - -
CHEMBL76 CHLOROQUINE IC50 - -
CHEMBL2435706 IC50 - -
CHEMBL2435705 IC50 > 10000.0 nM -
CHEMBL2435704 IC50 > 10000.0 nM -
CHEMBL2435703 IC50 - -
CHEMBL2435702 IC50 > 10000.0 nM -
CHEMBL2435701 IC50 > 10000.0 nM -
CHEMBL2435700 IC50 > 10000.0 nM -
CHEMBL2435699 IC50 - -
CHEMBL2435698 IC50 > 10000.0 nM -
CHEMBL2435697 IC50 > 10000.0 nM -
CHEMBL2435696 IC50 > 10000.0 nM -
CHEMBL2435695 IC50 > 10000.0 nM -
CHEMBL2435694 IC50 > 10000.0 nM -