Assay Detail
Functional
CHEMBL2439657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against late (4 to 5) gametocytic stage of Plasmodium falciparum after 72 hrs by image-based HTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Approaches to protozoan drug discovery: phenotypic screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.94 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207990 | EPOXOMYCIN | — | 1 | 9.15 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.46 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.34 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 5.89 |
| CHEMBL298470 | TAFENOQUINE | 4.0 | 1 | 5.47 |
| CHEMBL1630 | — | — | 1 | 5.35 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | - |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207990 | EPOXOMYCIN | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 3.43 | nM | 8.46 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL298470 | TAFENOQUINE | IC50 | = | 3366.0 | nM | 5.47 |
| CHEMBL1630 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | - | — | - | |
| CHEMBL307261 | ARTENIMOL | IC50 | - | — | - |