Assay Detail
Binding
CHEMBL2443393
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Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.78 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442996 | — | — | 1 | 7.95 |
| CHEMBL2442995 | — | — | 1 | 7.90 |
| CHEMBL2442994 | — | — | 1 | 7.82 |
| CHEMBL2442999 | — | — | 1 | 7.75 |
| CHEMBL2442997 | — | — | 1 | 7.63 |
| CHEMBL2442998 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442996 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL2442995 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL2442994 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL2442999 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2442997 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL2442998 | — | Ki | = | 23.8 | nM | 7.62 |