Assay Detail
Binding
CHEMBL2443397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-prazosin from alpha1-adrenergic receptor in pig cerebral cortex
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.52 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443009 | — | — | 1 | 6.96 |
| CHEMBL2443006 | — | — | 1 | 6.92 |
| CHEMBL2443004 | — | — | 1 | 6.92 |
| CHEMBL2443005 | — | — | 1 | 6.89 |
| CHEMBL2443008 | — | — | 1 | 6.68 |
| CHEMBL2443010 | — | — | 1 | 6.68 |
| CHEMBL2443007 | — | — | 1 | 6.58 |
| CHEMBL2443002 | — | — | 1 | 6.31 |
| CHEMBL2443000 | — | — | 1 | 6.31 |
| CHEMBL2443001 | — | — | 1 | 5.89 |
| CHEMBL2443003 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443009 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2443006 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2443004 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2443005 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2443008 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2443010 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2443007 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL2443002 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL2443000 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL2443001 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2443003 | — | Ki | = | 2500.0 | nM | 5.60 |