Assay Detail
Binding
CHEMBL2443399
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Displacement of [3H]WAY100635 from 5-HT1A in pig cerebral cortex
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.11 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443009 | — | — | 1 | 7.27 |
| CHEMBL2443010 | — | — | 1 | 6.62 |
| CHEMBL2443005 | — | — | 1 | 6.38 |
| CHEMBL2443004 | — | — | 1 | 6.38 |
| CHEMBL2443007 | — | — | 1 | 6.32 |
| CHEMBL2443006 | — | — | 1 | 6.25 |
| CHEMBL2443008 | — | — | 1 | 6.19 |
| CHEMBL2443001 | — | — | 1 | 6.11 |
| CHEMBL2443000 | — | — | 1 | 6.06 |
| CHEMBL2443002 | — | — | 1 | 4.92 |
| CHEMBL2443003 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443009 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL2443010 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL2443005 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL2443004 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL2443007 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL2443006 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL2443008 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL2443001 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL2443000 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL2443002 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL2443003 | — | Ki | = | 18000.0 | nM | 4.75 |