Assay Detail
Binding
CHEMBL2443400
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Displacement of [3H]spiperone from human D4.4 receptor expressed in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.34 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210232 | — | — | 1 | 8.57 |
| CHEMBL2443005 | — | — | 1 | 8.29 |
| CHEMBL2443004 | — | — | 1 | 7.85 |
| CHEMBL2443007 | — | — | 1 | 7.80 |
| CHEMBL2443009 | — | — | 1 | 7.70 |
| CHEMBL2443010 | — | — | 1 | 7.64 |
| CHEMBL2443008 | — | — | 1 | 7.50 |
| CHEMBL2443006 | — | — | 1 | 7.00 |
| CHEMBL2443000 | — | — | 1 | 6.82 |
| CHEMBL2443003 | — | — | 1 | 6.47 |
| CHEMBL2443002 | — | — | 1 | 6.30 |
| CHEMBL2443001 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210232 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL2443005 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL2443004 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2443007 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2443009 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2443010 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2443008 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL2443006 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2443000 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL2443003 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL2443002 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL2443001 | — | Ki | = | 680.0 | nM | 6.17 |