Assay Detail
Binding
CHEMBL2443404
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Displacement of [3H]SCH23390 from D1 receptor in pig striatal membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.53 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443007 | — | — | 1 | 5.44 |
| CHEMBL2443008 | — | — | 1 | 4.80 |
| CHEMBL2443010 | — | — | 1 | 4.68 |
| CHEMBL2443009 | — | — | 1 | 4.58 |
| CHEMBL210232 | — | — | 1 | 4.57 |
| CHEMBL2443000 | — | — | 1 | 4.52 |
| CHEMBL2443005 | — | — | 1 | 4.42 |
| CHEMBL2443006 | — | — | 1 | 4.37 |
| CHEMBL2443004 | — | — | 1 | 4.35 |
| CHEMBL2443002 | — | — | 1 | 4.27 |
| CHEMBL2443001 | — | — | 1 | 4.22 |
| CHEMBL2443003 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443007 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL2443008 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL2443010 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL2443009 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL210232 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL2443000 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL2443005 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL2443006 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL2443004 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL2443002 | — | Ki | = | 54000.0 | nM | 4.27 |
| CHEMBL2443001 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL2443003 | — | Ki | = | 77000.0 | nM | 4.11 |