Assay Detail
Binding
CHEMBL2443545
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Inhibition of Clostridium perfringens neuraminidase using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid sodium salt hydrate as substrate by fluorimetry
19
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium perfringens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bacterial neuraminidase inhibitory effects of prenylated isoflavones from roots of Flemingia philippinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.40 | 6.52 |
| Inhibition | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459129 | AURICULASIN | — | 2 | 6.52 |
| CHEMBL2442947 | — | — | 2 | 5.97 |
| CHEMBL2442948 | — | — | 2 | 5.79 |
| CHEMBL238188 | OSAJIN | — | 2 | 5.51 |
| CHEMBL2442946 | FLEMINGSIN | — | 2 | 5.43 |
| CHEMBL494252 | — | — | 2 | 5.39 |
| CHEMBL2442950 | — | — | 2 | 5.11 |
| CHEMBL2442949 | — | — | 2 | 5.10 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 4.92 |
| CHEMBL2442951 | — | — | 2 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459129 | AURICULASIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2442947 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL2442948 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL238188 | OSAJIN | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL2442946 | FLEMINGSIN | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL494252 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL2442950 | — | IC50 | = | 7850.0 | nM | 5.11 |
| CHEMBL2442949 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL44 | GENISTEIN | IC50 | = | 12050.0 | nM | 4.92 |
| CHEMBL2442951 | — | IC50 | = | 56800.0 | nM | 4.25 |
| CHEMBL2442951 | — | Inhibition | - | % | - | |
| CHEMBL494252 | — | Inhibition | - | % | - | |
| CHEMBL2442946 | FLEMINGSIN | Inhibition | - | % | - | |
| CHEMBL2442947 | — | Inhibition | - | % | - | |
| CHEMBL459129 | AURICULASIN | Inhibition | - | % | - | |
| CHEMBL2442948 | — | Inhibition | - | % | - | |
| CHEMBL2442949 | — | Inhibition | - | % | - | |
| CHEMBL238188 | OSAJIN | Inhibition | - | % | - | |
| CHEMBL2442950 | — | Inhibition | - | % | - |