Assay Detail
Functional
CHEMBL2443825
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Antiproliferative activity against human SKBR3 cells after 48 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and study of antiproliferative, antitopoisomerase II, DNA-intercalating and DNA-damaging activities of arylnaphthalimides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.43 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442956 | — | — | 1 | 6.52 |
| CHEMBL70270 | — | — | 1 | 6.10 |
| CHEMBL1644025 | — | — | 1 | 5.92 |
| CHEMBL2443054 | — | — | 1 | 5.92 |
| CHEMBL2443049 | — | — | 1 | 5.82 |
| CHEMBL2443053 | — | — | 1 | 5.36 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.13 |
| CHEMBL2442955 | — | — | 1 | 4.92 |
| CHEMBL2443055 | — | — | 1 | 4.85 |
| CHEMBL2442952 | — | — | 1 | 4.62 |
| CHEMBL2443052 | — | — | 1 | 4.56 |
| CHEMBL2443051 | — | — | 1 | - |
| CHEMBL2443050 | — | — | 1 | - |
| CHEMBL2442954 | — | — | 1 | - |
| CHEMBL2442953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442956 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL70270 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1644025 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2443054 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2443049 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2443053 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2442955 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL2443055 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL2442952 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2443052 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL2443051 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2443050 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2442954 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2442953 | — | IC50 | > | 30000.0 | nM | - |