Assay Detail
Binding
CHEMBL2443945
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Inhibition of GCN2 (unknown origin) assessed as EIF2AK4 phosphorylation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.79 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441342 | — | — | 1 | 6.11 |
| CHEMBL2441340 | — | — | 1 | 5.47 |
| CHEMBL2441346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441342 | — | IC50 | = | 776.0 | nM | 6.11 |
| CHEMBL2441340 | — | IC50 | = | 3388.0 | nM | 5.47 |
| CHEMBL2441346 | — | IC50 | - | — | - |