Assay Detail
Functional
CHEMBL2444050
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Cytotoxicity against human RPMI8226 cells after 48 to 72 hrs by SRB assay
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of bone-targeted proteasome inhibitors for multiple myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 5 | - | - |
| IC50 | 5 | 7.94 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 2 | 8.02 |
| CHEMBL2440763 | — | — | 2 | 7.99 |
| CHEMBL2440764 | — | — | 2 | 7.94 |
| CHEMBL2440765 | — | — | 2 | 7.90 |
| CHEMBL114388 | — | — | 2 | 7.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL2440763 | — | IC50 | = | 10.18 | nM | 7.99 |
| CHEMBL2440764 | — | IC50 | = | 11.51 | nM | 7.94 |
| CHEMBL2440765 | — | IC50 | = | 12.47 | nM | 7.90 |
| CHEMBL114388 | — | IC50 | = | 13.76 | nM | 7.86 |
| CHEMBL2440765 | — | Inhibition | - | % | - | |
| CHEMBL114388 | — | Inhibition | - | % | - | |
| CHEMBL2440764 | — | Inhibition | - | % | - | |
| CHEMBL2440763 | — | Inhibition | - | % | - | |
| CHEMBL325041 | BORTEZOMIB | Inhibition | - | % | - |