Assay Detail
Functional
CHEMBL2444089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimicrobial activity against Leishmania donovani MHOM/IN/00/DEVI amastigotes infected in mouse J774.1 cells after 120 hrs by microscopic analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Cell Type | J774.1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting the human parasite Leishmania donovani: discovery of a new promising anti-infectious pharmacophore in 3-nitroimidazo[1,2-a]pyridine series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.86 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.16 |
| CHEMBL2441910 | — | — | 1 | 5.26 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.17 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
| CHEMBL2441894 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2441910 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL55 | PENTAMIDINE | IC50 | > | 20000.0 | nM | - |
| CHEMBL2441894 | — | IC50 | > | 25000.0 | nM | - |