Assay Detail
Binding
CHEMBL2444356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant N-terminal His6-tagged AKR1B1 expressed in Escherichia coli by fluorescence assay in presence of NADPH
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.68 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2440411 | — | — | 1 | 8.17 |
| CHEMBL1172665 | — | — | 1 | 7.96 |
| CHEMBL2440426 | — | — | 1 | 7.92 |
| CHEMBL2440423 | — | — | 1 | 7.72 |
| CHEMBL2440427 | — | — | 1 | 7.70 |
| CHEMBL2440415 | — | — | 1 | 7.70 |
| CHEMBL2440422 | — | — | 1 | 7.62 |
| CHEMBL2440417 | — | — | 1 | 7.62 |
| CHEMBL2440425 | — | — | 1 | 7.60 |
| CHEMBL2440424 | — | — | 1 | 7.58 |
| CHEMBL2440414 | — | — | 1 | 7.57 |
| CHEMBL2440412 | — | — | 1 | 7.55 |
| CHEMBL2440413 | — | — | 1 | 7.55 |
| CHEMBL2440416 | — | — | 1 | 7.54 |
| CHEMBL2440428 | — | — | 1 | 7.47 |
| CHEMBL2440421 | — | — | 1 | - |
| CHEMBL2440418 | — | — | 1 | - |
| CHEMBL2440419 | — | — | 1 | - |
| CHEMBL2440420 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2440411 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1172665 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2440426 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2440423 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2440427 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2440415 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2440422 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2440417 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2440425 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2440424 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2440414 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2440412 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2440413 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2440416 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2440428 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2440421 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2440418 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2440419 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2440420 | — | IC50 | > | 10000.0 | nM | - |