Assay Detail
Functional
CHEMBL2444686
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Cytotoxicity against human PC3 cells after 72 hrs by vital dye exclusion/flow cytometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.91 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 5.01 |
| CHEMBL2441554 | — | — | 1 | 4.87 |
| CHEMBL2441555 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL2441554 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL2441555 | — | IC50 | = | 14300.0 | nM | 4.84 |