Assay Detail
Functional
CHEMBL2444710
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SW620 cells after 48 hrs by CellTiter-Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.78 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441567 | — | — | 1 | 5.21 |
| CHEMBL2441565 | — | — | 1 | 4.59 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441567 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2441565 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL939 | GEFITINIB | IC50 | = | 28200.0 | nM | 4.55 |