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Assay Detail

CHEMBL2445013

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to 5-HT6 receptor (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 6 (CHEMBL3371)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.
Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, Hopkins AL, Lefkowitz RJ, Navratilova I.
ACS Med Chem Lett (2013) 4 : 1005 -1010
PubMed 24454993 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.90 5.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2441619 1 5.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2441619 Ki = 1262.0 nM 5.90