Assay Detail
Binding
CHEMBL2445178
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Inhibition of Hsp90 in human BT474 cells assessed as degradation of Her2 protein level by immunocytochemistry assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.15 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443025 | — | — | 1 | 7.70 |
| CHEMBL2443024 | — | — | 1 | 7.60 |
| CHEMBL2443026 | — | — | 1 | 7.55 |
| CHEMBL2443136 | — | — | 1 | 7.50 |
| CHEMBL2443138 | — | — | 1 | 7.48 |
| CHEMBL2443139 | — | — | 1 | 7.19 |
| CHEMBL2443047 | — | — | 1 | 7.15 |
| CHEMBL2443131 | — | — | 1 | 7.15 |
| CHEMBL2443034 | — | — | 1 | 7.07 |
| CHEMBL2443135 | — | — | 1 | 7.06 |
| CHEMBL2443137 | — | — | 1 | 7.03 |
| CHEMBL2443020 | — | — | 1 | 6.97 |
| CHEMBL2443044 | — | — | 1 | 6.96 |
| CHEMBL2443029 | — | — | 1 | 6.94 |
| CHEMBL2443133 | — | — | 1 | 6.89 |
| CHEMBL2443132 | — | — | 1 | 6.68 |
| CHEMBL2443048 | — | — | 1 | 6.56 |
| CHEMBL3215941 | — | — | 1 | - |
| CHEMBL2443033 | — | — | 1 | - |
| CHEMBL2443022 | — | — | 1 | - |
| CHEMBL2443035 | — | — | 1 | - |
| CHEMBL2443036 | — | — | 1 | - |
| CHEMBL2443037 | — | — | 1 | - |
| CHEMBL2443038 | — | — | 1 | - |
| CHEMBL2443039 | — | — | 1 | - |
| CHEMBL2443040 | — | — | 1 | - |
| CHEMBL2443041 | — | — | 1 | - |
| CHEMBL2443042 | — | — | 1 | - |
| CHEMBL2443043 | — | — | 1 | - |
| CHEMBL2443021 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443025 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2443024 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2443026 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2443136 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2443138 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2443139 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2443047 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2443131 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2443034 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2443135 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2443137 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL2443020 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL2443044 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2443029 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL2443133 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2443132 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2443048 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL3215941 | — | IC50 | - | — | - | |
| CHEMBL2443033 | — | IC50 | - | — | - | |
| CHEMBL2443022 | — | IC50 | - | — | - | |
| CHEMBL2443035 | — | IC50 | - | — | - | |
| CHEMBL2443036 | — | IC50 | - | — | - | |
| CHEMBL2443037 | — | IC50 | - | — | - | |
| CHEMBL2443038 | — | IC50 | - | — | - | |
| CHEMBL2443039 | — | IC50 | - | — | - | |
| CHEMBL2443040 | — | IC50 | - | — | - | |
| CHEMBL2443041 | — | IC50 | - | — | - | |
| CHEMBL2443042 | — | IC50 | - | — | - | |
| CHEMBL2443043 | — | IC50 | - | — | - | |
| CHEMBL2443021 | — | IC50 | - | — | - | |
| CHEMBL2443045 | — | IC50 | - | — | - | |
| CHEMBL2443046 | — | IC50 | - | — | - | |
| CHEMBL2443134 | — | IC50 | - | — | - |