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Assay Detail

CHEMBL2445277

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tissue alpha-L-fucosidase (CHEMBL4176)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of N-(2-fluorophenyl)-2β-deoxyfuconojirimycin acetamide as a potent inhibitor for α-l-fucosidases.
Kato A, Okaki T, Ifuku S, Sato K, Hirokami Y, Iwaki R, Kamori A, Nakagawa S, Adachi I, Kiria PG, Onomura O, Minato D, Sugimoto K, Matsuya Y, Toyooka N.
Bioorg Med Chem (2013) 21 : 6565 -6573
PubMed 24026016 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.26 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2442786 1 8.10
CHEMBL2442788 1 7.85
CHEMBL2442783 1 7.82
CHEMBL2442784 1 7.72
CHEMBL2442779 1 7.58
CHEMBL2442777 1 7.52
CHEMBL2442782 1 7.52
CHEMBL2442787 1 7.51
CHEMBL2442773 1 7.46
CHEMBL2442781 1 7.24
CHEMBL2442776 1 7.07
CHEMBL2442780 1 6.89
CHEMBL314772 DEOXYFUCONOJIRIMYCIN 1 6.85
CHEMBL2442774 1 6.75
CHEMBL2442778 1 6.72
CHEMBL2442785 1 6.70
CHEMBL2442775 1 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2442786 IC50 = 7.9 nM 8.10
CHEMBL2442788 IC50 = 14.0 nM 7.85
CHEMBL2442783 IC50 = 15.0 nM 7.82
CHEMBL2442784 IC50 = 19.0 nM 7.72
CHEMBL2442779 IC50 = 26.0 nM 7.58
CHEMBL2442777 IC50 = 30.0 nM 7.52
CHEMBL2442782 IC50 = 30.0 nM 7.52
CHEMBL2442787 IC50 = 31.0 nM 7.51
CHEMBL2442773 IC50 = 35.0 nM 7.46
CHEMBL2442781 IC50 = 58.0 nM 7.24
CHEMBL2442776 IC50 = 86.0 nM 7.07
CHEMBL2442780 IC50 = 130.0 nM 6.89
CHEMBL314772 DEOXYFUCONOJIRIMYCIN IC50 = 140.0 nM 6.85
CHEMBL2442774 IC50 = 180.0 nM 6.75
CHEMBL2442778 IC50 = 190.0 nM 6.72
CHEMBL2442785 IC50 = 200.0 nM 6.70
CHEMBL2442775 IC50 = 890.0 nM 6.05