Assay Detail
Binding
CHEMBL2445382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GST-tagged Mcl1 expressed in Escherichia coli BL21 using FITC-AHA-MRPEIWIAQELRRIGDEFNA-[NH2] after 20 mins by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.98 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442249 | — | — | 1 | 6.51 |
| CHEMBL581146 | — | — | 1 | 6.40 |
| CHEMBL2442248 | — | — | 1 | 6.30 |
| CHEMBL2442247 | — | — | 1 | 5.92 |
| CHEMBL1468800 | — | — | 1 | 5.62 |
| CHEMBL2442246 | — | — | 1 | 5.12 |
| CHEMBL2442245 | — | — | 1 | - |
| CHEMBL2442244 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442249 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL581146 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2442248 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2442247 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1468800 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2442246 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL2442245 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2442244 | — | IC50 | > | 25000.0 | nM | - |