Assay Detail
Binding
CHEMBL2445786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to alpha7 nAChR (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and binding affinity of acetylcholine carbamoyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.27 | 4.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1472561 | — | — | 1 | 4.36 |
| CHEMBL965 | CARBAMOYLCHOLINE | 4.0 | 1 | 4.18 |
| CHEMBL1482 | BETHANECHOL | 4.0 | 1 | - |
| CHEMBL2441749 | 2-(DIMETHYLAMINO)ETHYL DIMETHYLCARBAMATE | — | 1 | - |
| CHEMBL2441748 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1472561 | — | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL965 | CARBAMOYLCHOLINE | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL1482 | BETHANECHOL | Ki | - | — | - | |
| CHEMBL2441749 | 2-(DIMETHYLAMINO)ETHYL DIMETHYLCARBAMATE | Ki | - | — | - | |
| CHEMBL2441748 | — | Ki | - | — | - |