Assay Detail
Binding
CHEMBL2445941
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]LSD from human recombinant 5HT6 receptor stably expressed in HEK cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.61 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442272 | — | — | 1 | 6.13 |
| CHEMBL2058704 | — | — | 1 | 6.07 |
| CHEMBL2058415 | — | — | 1 | 5.85 |
| CHEMBL2442274 | — | — | 1 | 5.85 |
| CHEMBL512332 | METHYLAPLYSINOPSIN | — | 1 | 5.76 |
| CHEMBL2058418 | — | — | 1 | 5.64 |
| CHEMBL2058703 | — | — | 1 | 5.43 |
| CHEMBL2058429 | — | — | 1 | 5.14 |
| CHEMBL2058426 | — | — | 1 | 5.12 |
| CHEMBL404232 | APLYSINOPSIN | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442272 | — | Ki | = | 742.0 | nM | 6.13 |
| CHEMBL2058704 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL2058415 | — | Ki | = | 1409.0 | nM | 5.85 |
| CHEMBL2442274 | — | Ki | = | 1405.0 | nM | 5.85 |
| CHEMBL512332 | METHYLAPLYSINOPSIN | Ki | = | 1716.0 | nM | 5.76 |
| CHEMBL2058418 | — | Ki | = | 2306.0 | nM | 5.64 |
| CHEMBL2058703 | — | Ki | = | 3733.0 | nM | 5.43 |
| CHEMBL2058429 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL2058426 | — | Ki | = | 7523.0 | nM | 5.12 |
| CHEMBL404232 | APLYSINOPSIN | Ki | = | 8768.0 | nM | 5.06 |