Assay Detail
Binding
CHEMBL2445944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]GR65630 from human recombinant 5HT3 receptor expressed in HEKT cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEKT |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.74 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2058426 | — | — | 1 | 6.23 |
| CHEMBL2058419 | — | — | 1 | 6.18 |
| CHEMBL1170237 | — | — | 1 | 6.00 |
| CHEMBL2058420 | — | — | 1 | 5.91 |
| CHEMBL512332 | METHYLAPLYSINOPSIN | — | 1 | 5.82 |
| CHEMBL2058427 | — | — | 1 | 5.58 |
| CHEMBL404232 | APLYSINOPSIN | — | 1 | 5.52 |
| CHEMBL2058415 | — | — | 1 | 5.23 |
| CHEMBL2058416 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2058426 | — | Ki | = | 591.0 | nM | 6.23 |
| CHEMBL2058419 | — | Ki | = | 656.0 | nM | 6.18 |
| CHEMBL1170237 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL2058420 | — | Ki | = | 1223.0 | nM | 5.91 |
| CHEMBL512332 | METHYLAPLYSINOPSIN | Ki | = | 1511.0 | nM | 5.82 |
| CHEMBL2058427 | — | Ki | = | 2624.0 | nM | 5.58 |
| CHEMBL404232 | APLYSINOPSIN | Ki | = | 3029.0 | nM | 5.52 |
| CHEMBL2058415 | — | Ki | = | 5916.0 | nM | 5.23 |
| CHEMBL2058416 | — | Ki | = | 6178.0 | nM | 5.21 |