Assay Detail
Binding
CHEMBL2446010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to alpha4beta2 nAChR (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design, synthesis and binding affinity of acetylcholine carbamoyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.68 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441748 | — | — | 1 | 7.70 |
| CHEMBL1472561 | — | — | 1 | 7.64 |
| CHEMBL965 | CARBAMOYLCHOLINE | 4.0 | 1 | 6.12 |
| CHEMBL2441749 | 2-(DIMETHYLAMINO)ETHYL DIMETHYLCARBAMATE | — | 1 | 5.24 |
| CHEMBL1482 | BETHANECHOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441748 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1472561 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL965 | CARBAMOYLCHOLINE | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL2441749 | 2-(DIMETHYLAMINO)ETHYL DIMETHYLCARBAMATE | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL1482 | BETHANECHOL | Ki | - | — | - |