Assay Detail
Binding
CHEMBL2446014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human neutrophil elastase
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 4 | - | - |
| IC50 | 4 | 5.11 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441773 | — | — | 2 | 5.11 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 2 | 5.10 |
| CHEMBL4525964 | VANIPREVIR | 3.0 | 2 | - |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441773 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL231813 | TELAPREVIR | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2441773 | — | IC90 | = | 85000.0 | nM | - |
| CHEMBL231813 | TELAPREVIR | IC90 | > | 100000.0 | nM | - |
| CHEMBL4525964 | VANIPREVIR | IC90 | > | 100000.0 | nM | - |
| CHEMBL218394 | BOCEPREVIR | IC90 | > | 100000.0 | nM | - |
| CHEMBL4525964 | VANIPREVIR | IC50 | > | 100000.0 | nM | - |
| CHEMBL218394 | BOCEPREVIR | IC50 | >= | 100000.0 | nM | - |