Assay Detail

CHEMBL2446028

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Binding

Inhibition of Hepatitis C virus genotype 1b NS3/4A protease D168V mutant

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Hepatitis C virus subtype 1b
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.

Bondada L, Rondla R, Pradere U, Liu P, Li C, Bobeck D, McBrayer T, Tharnish P, Courcambeck J, Halfon P, Whitaker T, Amblard F, Coats SJ, Schinazi RF.
Bioorg Med Chem Lett (2013) 23 : 6325 -6330
PubMed 24135727 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC90	4	-	-
EC50	4	6.72	7.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL231813	TELAPREVIR	4.0	2	7.10
CHEMBL218394	BOCEPREVIR	4.0	2	6.66
CHEMBL2441773	—	—	2	6.40
CHEMBL4525964	VANIPREVIR	3.0	2	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL231813	TELAPREVIR	EC50	=	80.0	nM	7.10
CHEMBL218394	BOCEPREVIR	EC50	=	220.0	nM	6.66
CHEMBL2441773	—	EC50	=	400.0	nM	6.40
CHEMBL4525964	VANIPREVIR	EC90	>	1.0	uM	-
CHEMBL2441773	—	EC90	=	3.3	uM	-
CHEMBL231813	TELAPREVIR	EC90	=	0.74	uM	-
CHEMBL218394	BOCEPREVIR	EC90	=	0.9	uM	-
CHEMBL4525964	VANIPREVIR	EC50	>	1000.0	nM	-