Assay Detail
Binding
CHEMBL2446068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MGAT2 by LC/MS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
2-acylglycerol O-acyltransferase 2 (CHEMBL2439944) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fighting Obesity and Metabolic Disorders with MGAT-2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.98 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441597 | — | — | 1 | 8.70 |
| CHEMBL2441598 | — | — | 1 | 8.15 |
| CHEMBL2441600 | — | — | 1 | 8.15 |
| CHEMBL2441599 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441597 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2441598 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2441600 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2441599 | — | IC50 | = | 121.0 | nM | 6.92 |