Assay Detail
Binding
CHEMBL2446342
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Inhibition of Escherichia coli RNA polymerase core enzyme by transcription assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel bacterial RNA polymerase inhibitors: pharmacophore-based virtual screening and hit optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.83 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 7.80 |
| CHEMBL2440261 | — | — | 1 | 4.92 |
| CHEMBL2440259 | — | — | 1 | 4.57 |
| CHEMBL175848 | — | — | 1 | 4.44 |
| CHEMBL2440280 | — | — | 1 | 4.41 |
| CHEMBL242621 | — | — | 1 | 4.24 |
| CHEMBL2440270 | — | — | 1 | 4.17 |
| CHEMBL373673 | — | — | 1 | 4.09 |
| CHEMBL2440275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2440261 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2440259 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL175848 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL2440280 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL242621 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL2440270 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL373673 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL2440275 | — | IC50 | - | — | - |