Assay Detail
Binding
CHEMBL2446346
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Inhibition of Escherichia coli RNA polymerase-RNA polymerase sigma factor RpoD interaction by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel bacterial RNA polymerase inhibitors: pharmacophore-based virtual screening and hit optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.30 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242621 | — | — | 1 | 4.52 |
| CHEMBL2440261 | — | — | 1 | 4.48 |
| CHEMBL175848 | — | — | 1 | 4.39 |
| CHEMBL2440259 | — | — | 1 | 4.33 |
| CHEMBL2440270 | — | — | 1 | 4.22 |
| CHEMBL2440280 | — | — | 1 | 4.17 |
| CHEMBL373673 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242621 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2440261 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL175848 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2440259 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL2440270 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL2440280 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL373673 | — | IC50 | = | 97000.0 | nM | 4.01 |