Assay Detail
Binding
CHEMBL2446522
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Inhibition of human recombinant carbonic anhydrase9 transmembrane isoform expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydration assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of human carbonic anhydrase isoforms I-XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.97 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443313 | — | — | 1 | 7.66 |
| CHEMBL2443314 | — | — | 1 | 7.65 |
| CHEMBL186716 | — | — | 1 | 6.82 |
| CHEMBL2443317 | — | — | 1 | 6.70 |
| CHEMBL2443315 | — | — | 1 | 6.68 |
| CHEMBL2443318 | — | — | 1 | 6.67 |
| CHEMBL2443316 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443313 | — | Ki | = | 21.8 | nM | 7.66 |
| CHEMBL2443314 | — | Ki | = | 22.3 | nM | 7.65 |
| CHEMBL186716 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL2443317 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL2443315 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL2443318 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL2443316 | — | Ki | = | 228.0 | nM | 6.64 |