Assay Detail
Binding
CHEMBL2446582
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Inhibition of human recombinant MMP-2 using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.55 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063274 | — | — | 1 | 8.22 |
| CHEMBL2442885 | — | — | 1 | 7.30 |
| CHEMBL2442889 | — | — | 1 | 6.80 |
| CHEMBL2442890 | — | — | 1 | 6.64 |
| CHEMBL2442881 | — | — | 1 | 6.62 |
| CHEMBL2442886 | — | — | 1 | 6.54 |
| CHEMBL2442891 | — | — | 1 | 6.51 |
| CHEMBL2442893 | — | — | 1 | 6.41 |
| CHEMBL2442884 | — | — | 1 | 6.38 |
| CHEMBL2442882 | — | — | 1 | 6.36 |
| CHEMBL2442892 | — | — | 1 | 6.32 |
| CHEMBL2442887 | — | — | 1 | 6.31 |
| CHEMBL2442878 | — | — | 1 | 6.26 |
| CHEMBL2442883 | — | — | 1 | 6.25 |
| CHEMBL2442888 | — | — | 1 | 6.17 |
| CHEMBL2442880 | — | — | 1 | 6.16 |
| CHEMBL2442879 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063274 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2442885 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL2442889 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2442890 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL2442881 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL2442886 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL2442891 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL2442893 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL2442884 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL2442882 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL2442892 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL2442887 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL2442878 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL2442883 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL2442888 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL2442880 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL2442879 | — | Ki | = | 760.0 | nM | 6.12 |