Assay Detail
Functional
CHEMBL2446689
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cytostim-induced IFNgamma production in human PBMC treated 1 hr before cytostim stimulation measured after 18 hrs by MSD assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.45 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441112 | — | — | 1 | 7.60 |
| CHEMBL2441273 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441112 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL2441273 | — | IC50 | = | 50.12 | nM | 7.30 |