Assay Detail
Binding
CHEMBL2446690
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Inhibition of LCK (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.30 | 6.30 |
| IC50 | 1 | 6.90 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441273 | — | — | 1 | 6.90 |
| CHEMBL2441279 | — | — | 1 | 6.30 |
| CHEMBL2441278 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441273 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL2441279 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL2441278 | — | Ki | = | 501.19 | nM | 6.30 |