Assay Detail
Functional
CHEMBL2447127
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Growth inhibition of mouse L1210 cells after 72 hrs by phosphatase assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.58 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441610 | — | — | 1 | 9.29 |
| CHEMBL2441607 | — | — | 1 | 9.28 |
| CHEMBL2441611 | — | — | 1 | 9.21 |
| CHEMBL3037931 | — | — | 1 | 9.21 |
| CHEMBL2441612 | — | — | 1 | 9.15 |
| CHEMBL2441605 | — | — | 1 | 8.68 |
| CHEMBL2441608 | — | — | 1 | 8.28 |
| CHEMBL2314560 | — | — | 1 | 8.28 |
| CHEMBL2314561 | — | — | 1 | 8.26 |
| CHEMBL2314533 | — | — | 1 | 8.23 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.22 |
| CHEMBL2441606 | — | — | 1 | 8.11 |
| CHEMBL2314532 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441610 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL2441607 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL2441611 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL3037931 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL2441612 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2441605 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2441608 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2314560 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2314561 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL2314533 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2441606 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL2314532 | — | IC50 | = | 40.0 | nM | 7.40 |