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Assay Detail

CHEMBL2447435

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Dengue virus 2 infected in human Huh-7 cells assessed as inhibition of viral replication after 48 hrs by luciferase reporter gene assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism dengue virus type 2
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

dengue virus type 2 (CHEMBL613966)
Type ORGANISM
Organism dengue virus type 2

Publication

Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture.
Nitsche C, Schreier VN, Behnam MA, Kumar A, Bartenschlager R, Klein CD.
J Med Chem (2013) 56 : 8389 -8403
PubMed 24083834 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 4.47 4.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2440173 1 4.78
CHEMBL2440162 1 4.59
CHEMBL2440336 1 4.58
CHEMBL2440349 1 4.57
CHEMBL2440335 1 4.52
CHEMBL2440172 1 4.52
CHEMBL2440176 1 4.50
CHEMBL2440161 1 4.50
CHEMBL2440156 1 4.45
CHEMBL2440322 1 4.45
CHEMBL2440159 1 4.43
CHEMBL2440347 1 4.43
CHEMBL2440346 1 4.39
CHEMBL2440154 1 4.37
CHEMBL2440353 1 4.35
CHEMBL2440175 1 4.31
CHEMBL2440332 1 4.27
CHEMBL2440164 1 -
CHEMBL2440356 1 -
CHEMBL2440352 1 -
CHEMBL2440179 1 -
CHEMBL2440177 1 -
CHEMBL2440331 1 -
CHEMBL2440334 1 -
CHEMBL2440167 1 -
CHEMBL2440166 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2440173 EC50 = 16700.0 nM 4.78
CHEMBL2440162 EC50 = 25600.0 nM 4.59
CHEMBL2440336 EC50 = 26000.0 nM 4.58
CHEMBL2440349 EC50 = 26800.0 nM 4.57
CHEMBL2440335 EC50 = 30300.0 nM 4.52
CHEMBL2440172 EC50 = 30300.0 nM 4.52
CHEMBL2440176 EC50 = 31300.0 nM 4.50
CHEMBL2440161 EC50 = 31500.0 nM 4.50
CHEMBL2440156 EC50 = 35700.0 nM 4.45
CHEMBL2440322 EC50 = 35500.0 nM 4.45
CHEMBL2440159 EC50 = 37300.0 nM 4.43
CHEMBL2440347 EC50 = 37200.0 nM 4.43
CHEMBL2440346 EC50 = 41100.0 nM 4.39
CHEMBL2440154 EC50 = 42500.0 nM 4.37
CHEMBL2440353 EC50 = 44900.0 nM 4.35
CHEMBL2440175 EC50 = 48800.0 nM 4.31
CHEMBL2440332 EC50 = 53800.0 nM 4.27
CHEMBL2440164 EC50 > 50000.0 nM -
CHEMBL2440356 EC50 > 50000.0 nM -
CHEMBL2440352 EC50 > 50000.0 nM -
CHEMBL2440179 EC50 > 50000.0 nM -
CHEMBL2440177 EC50 > 50000.0 nM -
CHEMBL2440331 EC50 > 50000.0 nM -
CHEMBL2440334 EC50 > 50000.0 nM -
CHEMBL2440167 EC50 > 50000.0 nM -
CHEMBL2440166 EC50 > 50000.0 nM -