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Assay Detail

CHEMBL2447442

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Dengue virus NS2B-NS3 protease expressed in Escherichia coli BL 21 (DE3) using Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr as substrate assessed as enzyme-substrate-inhibitor complex by Cornish-Bowden plot analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Dengue virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture.
Nitsche C, Schreier VN, Behnam MA, Kumar A, Bartenschlager R, Klein CD.
J Med Chem (2013) 56 : 8389 -8403
PubMed 24083834 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 5.18 5.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2440173 1 5.36
CHEMBL2440162 1 5.29
CHEMBL2440175 1 5.28
CHEMBL2440345 1 5.28
CHEMBL2440346 1 5.27
CHEMBL2440157 1 5.26
CHEMBL2440158 1 5.12
CHEMBL2440353 1 5.10
CHEMBL2440160 1 5.10
CHEMBL2440159 1 5.08
CHEMBL2440161 1 5.07
CHEMBL2440172 1 5.00
CHEMBL2440357 1 -
CHEMBL2440343 1 -
CHEMBL2440342 1 -
CHEMBL2440341 1 -
CHEMBL2440340 1 -
CHEMBL2440339 1 -
CHEMBL2440347 1 -
CHEMBL2440344 1 -
CHEMBL2440165 1 -
CHEMBL2440322 1 -
CHEMBL2440354 1 -
CHEMBL2440352 1 -
CHEMBL2440164 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2440173 Ki = 4400.0 nM 5.36
CHEMBL2440162 Ki = 5100.0 nM 5.29
CHEMBL2440175 Ki = 5300.0 nM 5.28
CHEMBL2440345 Ki = 5200.0 nM 5.28
CHEMBL2440346 Ki = 5400.0 nM 5.27
CHEMBL2440157 Ki = 5500.0 nM 5.26
CHEMBL2440158 Ki = 7600.0 nM 5.12
CHEMBL2440353 Ki = 7900.0 nM 5.10
CHEMBL2440160 Ki = 7900.0 nM 5.10
CHEMBL2440159 Ki = 8300.0 nM 5.08
CHEMBL2440161 Ki = 8600.0 nM 5.07
CHEMBL2440172 Ki = 10000.0 nM 5.00
CHEMBL2440357 Ki > 10000.0 nM -
CHEMBL2440343 Ki > 50000.0 nM -
CHEMBL2440342 Ki > 50000.0 nM -
CHEMBL2440341 Ki > 50000.0 nM -
CHEMBL2440340 Ki > 50000.0 nM -
CHEMBL2440339 Ki > 50000.0 nM -
CHEMBL2440347 Ki > 10000.0 nM -
CHEMBL2440344 Ki > 10000.0 nM -
CHEMBL2440165 Ki > 10000.0 nM -
CHEMBL2440322 Ki > 10000.0 nM -
CHEMBL2440354 Ki > 10000.0 nM -
CHEMBL2440352 Ki > 10000.0 nM -
CHEMBL2440164 Ki > 10000.0 nM -