Assay Detail
Binding
CHEMBL2447572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to sigma 2 receptor (unknown origin) by radioligand binding assay
10
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.87 | 6.45 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442996 | — | — | 1 | 6.45 |
| CHEMBL2442995 | — | — | 1 | 6.20 |
| CHEMBL2442994 | — | — | 1 | 5.46 |
| CHEMBL522691 | — | — | 1 | 5.38 |
| CHEMBL2442999 | — | — | 2 | - |
| CHEMBL2442998 | — | — | 2 | - |
| CHEMBL2442997 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442996 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL2442995 | — | Ki | = | 638.0 | nM | 6.20 |
| CHEMBL2442994 | — | Ki | = | 3480.0 | nM | 5.46 |
| CHEMBL522691 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL2442999 | — | Inhibition | = | 45.0 | % | - |
| CHEMBL2442998 | — | Inhibition | = | 38.0 | % | - |
| CHEMBL2442997 | — | Inhibition | = | 39.0 | % | - |
| CHEMBL2442999 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2442998 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2442997 | — | Ki | > | 10000.0 | nM | - |