Assay Detail
Binding
CHEMBL2447590
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]GR113808 from human 5HT4B receptor expressed in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.59 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33884 | — | — | 1 | 10.40 |
| CHEMBL2440460 | — | — | 1 | 10.30 |
| CHEMBL2440457 | — | — | 1 | 10.20 |
| CHEMBL356359 | PIBOSEROD | 2.0 | 1 | 10.00 |
| CHEMBL2440458 | — | — | 1 | 9.20 |
| CHEMBL2440456 | — | — | 1 | 8.60 |
| CHEMBL2440455 | — | — | 1 | 8.40 |
| CHEMBL2440459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33884 | — | Ki | = | 0.03981 | nM | 10.40 |
| CHEMBL2440460 | — | Ki | = | 0.05012 | nM | 10.30 |
| CHEMBL2440457 | — | Ki | = | 0.0631 | nM | 10.20 |
| CHEMBL356359 | PIBOSEROD | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL2440458 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL2440456 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL2440455 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL2440459 | — | Ki | = | 0.001259 | nM | - |