Assay Detail
Functional
CHEMBL3047044
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Antispasmodic activity in rat ileum assessed as inhibition of histamine-induced contraction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sesquiterpene lactones: antispasmodic principles of the freshwater algae Hydrodictyon reticulatum
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.82 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19224 | PAPAVERINE | 3.0 | 1 | 8.21 |
| CHEMBL2237473 | — | — | 1 | 7.83 |
| CHEMBL2237191 | — | — | 1 | 7.71 |
| CHEMBL508894 | (-)-CARYOPHYLLENE OXIDE | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19224 | PAPAVERINE | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL2237473 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL2237191 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL508894 | (-)-CARYOPHYLLENE OXIDE | IC50 | = | 30.0 | nM | 7.52 |