Assay Detail
Binding
CHEMBL3047468
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Inhibition of Homo sapiens (human) HDAC8
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An efficient anticancer histone deacetylase inhibitor and its analogues for human HDAC8
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 6.55 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2235264 | — | — | 1 | 8.70 |
| CHEMBL2235262 | — | — | 1 | 8.40 |
| CHEMBL2235266 | — | — | 1 | 8.35 |
| CHEMBL2235260 | — | — | 1 | 8.30 |
| CHEMBL2235657 | — | — | 1 | 8.22 |
| CHEMBL2235263 | — | — | 1 | 8.10 |
| CHEMBL2235261 | — | — | 1 | 8.07 |
| CHEMBL2235265 | — | — | 1 | 8.02 |
| CHEMBL2235257 | — | — | 1 | 7.82 |
| CHEMBL2235251 | — | — | 1 | 7.70 |
| CHEMBL2235658 | — | — | 1 | 7.60 |
| CHEMBL95273 | — | — | 1 | 7.46 |
| CHEMBL2235659 | — | — | 1 | 7.46 |
| CHEMBL2235258 | — | — | 1 | 7.35 |
| CHEMBL2235259 | — | — | 1 | 7.35 |
| CHEMBL2235664 | — | — | 1 | 7.22 |
| CHEMBL99810 | — | — | 1 | 7.19 |
| CHEMBL2235253 | — | — | 1 | 7.15 |
| CHEMBL318642 | — | — | 1 | 7.12 |
| CHEMBL2235665 | — | — | 1 | 7.05 |
| CHEMBL2235256 | — | — | 1 | 7.02 |
| CHEMBL98346 | — | — | 1 | 7.00 |
| CHEMBL2235662 | — | — | 1 | 7.00 |
| CHEMBL96966 | — | — | 1 | 7.00 |
| CHEMBL95195 | — | — | 1 | 7.00 |
| CHEMBL95850 | — | — | 1 | 7.00 |
| CHEMBL149606 | — | — | 1 | 6.99 |
| CHEMBL2235254 | — | — | 1 | 6.87 |
| CHEMBL2235255 | — | — | 1 | 6.82 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2235264 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2235262 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2235266 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL2235260 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2235657 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2235263 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2235261 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL2235265 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL2235257 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2235251 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2235658 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL95273 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2235659 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2235258 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2235259 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2235664 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL99810 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2235253 | — | IC50 | = | 71.4 | nM | 7.15 |
| CHEMBL318642 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2235665 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2235256 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL95850 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL95195 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2235662 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL98346 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL96966 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL149606 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL2235254 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL2235255 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL317814 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL317570 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL95849 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL555906 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL95835 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2235252 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL95959 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL556332 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2235267 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL97384 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL97387 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2235663 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL552465 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL319248 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL97860 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2235666 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL95916 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL551151 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2235660 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL557560 | — | IC50 | = | 2000.0 | nM | 5.70 |