Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3049693

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to adrenergic alpha1A receptor (unknown origin)
ChEMBL ↗
88
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Alpha-1A adrenergic receptor (CHEMBL229) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3D-QSAR CoMFA and CoMSIA studies on a set of diverse 1a-adrenergic receptor antagonists
Gupta AK, Saxena AK
Med Chem Res (2011) 20 : 1455 -1464
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 88 7.51 10.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2234441 — — 2 10.30
CHEMBL2234443 — — 2 10.10
CHEMBL198860 — — 2 9.60
CHEMBL197442 — — 2 9.50
CHEMBL25554 — — 2 9.37
CHEMBL2 PRAZOSIN 4.0 2 9.23
CHEMBL59262 — — 2 8.84
CHEMBL200366 — — 2 8.70
CHEMBL427552 — — 2 8.70
CHEMBL2234442 — — 2 8.63
CHEMBL60583 — — 2 8.55
CHEMBL142635 NAFTOPIDIL 4.0 2 8.23
CHEMBL2234446 — — 2 8.10
CHEMBL2234444 — — 2 8.06
CHEMBL57540 — — 2 7.63
CHEMBL1178679 — — 2 7.61
CHEMBL2234447 — — 2 7.54
CHEMBL1178700 — — 2 7.47
CHEMBL301224 — — 2 7.47
CHEMBL2234445 — — 2 7.44
CHEMBL299253 — — 2 7.37
CHEMBL56620 — — 2 7.26
CHEMBL299454 — — 2 7.16
CHEMBL2234456 — — 2 7.13
CHEMBL143026 — — 2 7.07
CHEMBL293539 — — 2 7.07
CHEMBL2234448 — — 2 7.04
CHEMBL2234449 — — 2 7.02
CHEMBL431354 — — 2 7.02
CHEMBL59149 — — 2 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2234441 — Ki = 0.05012 nM 10.30
CHEMBL2234441 — Ki = 0.05 nM 10.30
CHEMBL2234443 — Ki = 0.08 nM 10.10
CHEMBL2234443 — Ki = 0.08913 nM 10.05
CHEMBL198860 — Ki = 0.251 nM 9.60
CHEMBL198860 — Ki = 0.2512 nM 9.60
CHEMBL197442 — Ki = 0.3162 nM 9.50
CHEMBL197442 — Ki = 0.316 nM 9.50
CHEMBL25554 — Ki = 0.426 nM 9.37
CHEMBL25554 — Ki = 0.4266 nM 9.37
CHEMBL2 PRAZOSIN Ki = 0.5888 nM 9.23
CHEMBL2 PRAZOSIN Ki = 0.588 nM 9.23
CHEMBL59262 — Ki = 1.445 nM 8.84
CHEMBL59262 — Ki = 1.448 nM 8.84
CHEMBL200366 — Ki = 1.995 nM 8.70
CHEMBL427552 — Ki = 1.995 nM 8.70
CHEMBL427552 — Ki = 1.99 nM 8.70
CHEMBL200366 — Ki = 1.99 nM 8.70
CHEMBL2234442 — Ki = 2.344 nM 8.63
CHEMBL2234442 — Ki = 2.34 nM 8.63
CHEMBL60583 — Ki = 2.818 nM 8.55
CHEMBL60583 — Ki = 2.832 nM 8.55
CHEMBL142635 NAFTOPIDIL Ki = 5.888 nM 8.23
CHEMBL142635 NAFTOPIDIL Ki = 5.88 nM 8.23
CHEMBL2234446 — Ki = 7.943 nM 8.10
CHEMBL2234446 — Ki = 7.94 nM 8.10
CHEMBL2234444 — Ki = 8.71 nM 8.06
CHEMBL2234444 — Ki = 8.7 nM 8.06
CHEMBL57540 — Ki = 23.4 nM 7.63
CHEMBL57540 — Ki = 23.44 nM 7.63
CHEMBL1178679 — Ki = 24.54 nM 7.61
CHEMBL2234447 — Ki = 28.84 nM 7.54
CHEMBL2234447 — Ki = 28.84 nM 7.54
CHEMBL301224 — Ki = 33.88 nM 7.47
CHEMBL301224 — Ki = 33.93 nM 7.47
CHEMBL1178700 — Ki = 33.88 nM 7.47
CHEMBL1178679 — Ki = 33.88 nM 7.47
CHEMBL2234445 — Ki = 36.3 nM 7.44
CHEMBL2234445 — Ki = 36.31 nM 7.44
CHEMBL299253 — Ki = 43.14 nM 7.37
CHEMBL299253 — Ki = 43.65 nM 7.36
CHEMBL56620 — Ki = 54.95 nM 7.26
CHEMBL56620 — Ki = 54.61 nM 7.26
CHEMBL299454 — Ki = 70.04 nM 7.16
CHEMBL299454 — Ki = 70.79 nM 7.15
CHEMBL2234456 — Ki = 74.13 nM 7.13
CHEMBL2234456 — Ki = 74.13 nM 7.13
CHEMBL143026 — Ki = 85.11 nM 7.07
CHEMBL293539 — Ki = 86.16 nM 7.07
CHEMBL143026 — Ki = 85.11 nM 7.07